Highlights:
- New ラーメンベット 登録方法 tattoo functions like a classical pacemaker but with improved conformability to soft, moving tissues and superior electrical and optical properties
- In tests, the ラーメンベット 登録方法 tattoo sensed irregular heartbeats and delivered electrical stimulation to correct the rhythm
- The device also is transparent, allowing recording and stimulation of the ラーメンベット 登録方法 with optical light using optogenetics
A new cardiac implant made from ラーメンベット 登録方法, a two-dimensional supermaterial with ultra-strong, lightweight and conductive properties, functions like a classic pacemaker with some major improvements.
A team led by researchers from The University of Texas at Austin and Northwestern University developed the implantable derivative from wearable ラーメンベット 登録方法-based electronic tattoo, or e-tattoo – ラーメンベット 登録方法 biointerface. The device, detailed in the journal Advanced Materials, marks the thinnest known cardiac implant to date.
“It’s very exciting to take our e-tattoo technology and use it as an implantable device inside the body,” said Dmitry Kireev, a postdoctoral research associate in the lab of professor Deji Akinwande’s lab at UT Austin who co-led the research. “The fact that is much more compatible with the human body, lightweight, and transparent, makes this a more natural solution for people dealing with ラーメンベット 登録方法 problems.”
The researchers demonstrated that the graphene tattoo could successfully sense irregular ラーメンベット 登録方法 rhythms and then deliver electrical stimulation through a series of pulses without constraining or altering the ラーメンベット 登録方法’s natural motions. Even better: The technology also is optically transparent, allowing researchers access to use an external source of optical light to record and stimulate the ラーメンベット 登録方法 activity through the device.
Similar in appearance to a child’s temporary tattoo, the new graphene “tattoo” implant is thinner than a single strand of hair. Unlike current pacemakers and implanted defibrillators, which require hard, rigid materials that are mechanically incompatible with the body, the new device softly melds to the ラーメンベット 登録方法 to simultaneously sense and treat irregular heartbeats. The implant is thin and flexible enough to conform to the ラーメンベット 登録方法’s delicate contours as well as stretchy and strong enough to withstand the dynamic motions of a beating ラーメンベット 登録方法.
“One of the challenges for current pacemakers and defibrillators is that they are difficult to affix onto the surface of the ラーメンベット 登録方法,” said Northwestern’s Igor Efimov, a professor of biomedical ラーメンベット 登録方法 at the McCormick School of ラーメンベット 登録方法 who co-led the study. “Defibrillator electrodes, for example, are essentially coils made of very thick wires. These wires are not flexible, and they break. Rigid interfaces with soft tissues, like the ラーメンベット 登録方法, can cause various complications. By contrast, our soft, flexible device is not only unobtrusive but also intimately and seamlessly conforms directly onto the ラーメンベット 登録方法 to deliver more precise measurements.”
Miracle material
Known as cardiac arrhythmias, ラーメンベット 登録方法 rhythm disorders occur when the ラーメンベット 登録方法 beats either too quickly or too slowly. While some cases of arrhythmia are not serious, many cases can lead to ラーメンベット 登録方法 failure, stroke and even sudden death. In fact, complications related to arrhythmia claim about 300,000 lives annually in the United States. Physicians commonly treat arrhythmia with implantable pacemakers and defibrillators that detect abnormal heartbeats and then correct rhythm with electrical stimulation. While these devices are lifesaving, their rigid nature may constrain the ラーメンベット 登録方法’s natural motions, injure soft tissues, cause temporary discomfort and induce complications, such as painful swelling, perforations, blood clots, infection and more.
With these challenges in mind, Efimov and his team sought to develop a bio-compatible device ideal for conforming to soft, dynamic tissues. After reviewing multiple materials, the researchers settled on ラーメンベット 登録方法, an atomically thin form of carbon. With its ultra-strong, lightweight structure and superior conductivity, ラーメンベット 登録方法 has potential for many applications in high-performance electronics, high-strength materials and energy devices.
“For bio-compatibility reasons, ラーメンベット 登録方法 is particularly attractive,” Efimov said. “Carbon is the basis of life, so it’s a safe material that is already used in different clinical applications. It also is flexible and soft, which works well as an interface between electronics and a soft, mechanically active organ.”
Hitting a beating target
At UT Austin, Akinwande and his team had been developing e-tattoos using graphene for several years, with a variety of functions, including monitoring body signals. Flexible and weightless, their team’s e-tattoos adhere to the skin to continuously monitor the body’s vital signs, including blood pressure and the electrical activity of the brain, ラーメンベット 登録方法 and muscles.
But, while the e-tattoos work well on the skin’s surface, the researchers needed to find new ways to deploy these devices inside the body — directly onto the surface of the ラーメンベット 登録方法.
“The conditions inside the body are very different compared to affixing a device to the skin, so we had to re-imagine how we package our e-tattoo technology,” said Akinwande, a professor in the Chandra Family Department of Electrical and Computer ラーメンベット 登録方法.
The researchers developed an entirely new technique to encase the graphene tattoo and adhere it to the surface of a beating ラーメンベット 登録方法. First, they encapsulated the graphene inside a flexible, elastic silicone membrane — with a hole punched in it to give access to the interior graphene electrode. Then, they gently placed gold tape (with a thickness of 10 microns) onto the encapsulating layer to serve as an electrical interconnect between the graphene and the external electronics used to measure and stimulate the ラーメンベット 登録方法. Finally, they placed it onto the ラーメンベット 登録方法. The entire thickness of all layers together measures about 100 microns in total.
The resulting device was stable for 60 days on an actively beating ラーメンベット 登録方法 at body temperature, which is comparable to the duration of temporary pacemakers used as bridges to permanent pacemakers or rhythm management after surgery or other therapies.
Optical opportunities
Leveraging the device’s transparent nature, Efimov and his team tested out optocardiography — using light to track and modulate ラーメンベット 登録方法 rhythm. Not only does this offer a new way to diagnose and treat ラーメンベット 登録方法 ailments, the approach also opens new possibilities for optogenetics, a method to control and monitor single cells with light.
While electrical stimulation can correct a ラーメンベット 登録方法’s abnormal rhythm, optical stimulation is more precise. With light, researchers can track specific enzymes as well as interrogate specific ラーメンベット 登録方法, muscle or nerve cells.
“We can essentially combine electrical and optical functions into one biointerface,” Efimov said. “Because ラーメンベット 登録方法 is optically transparent, we can actually read through it, which gives us a much higher density of readout.”
Grants from the National Institutes of Health, the Leducq Foundation, the Office of Naval ラーメンベット 登録方法 and the Temple Foundation. Other members of the ラーメンベット 登録方法 team are Ning Liu from the Chandra Family Department of Electrical and Computer Engineering at UT Austin and Zexu Lin; Shubham Gupta, Sofian Obaid and Zhiyuan Chen of The George Washington University; and Jessica LaPaino of MedStar Georgetown University Hospital.
