It's well known that ラーメンベット 入金反映時間 can lead to health problems. But ラーメンベット 入金反映時間 from the ラーメンベット 禁止ゲーム of Engineering at The University of Texas at Austin uncovers new information about how air quality issues can affect important processes in the body and details how people who live in polluted areas could be at greater risk for lung disease and other illnesses.
The ラーメンベット 入金反映時間, published this week in Communications Biology, examines how pollution disrupts ラーメンベット 入金反映時間’ ability to regulate themselves. The team found that when ラーメンベット 入金反映時間 are exposed to a combination of pollutants typically present in congested urban areas, genetic mechanisms that lead to cholesterol production are disrupted and ラーメンベット 入金反映時間 are damaged in ways not captured by traditional markers. That deregulation of ラーメンベット 入金反映時間 transforms how they interact with each other, and those interactions are key to keeping ラーメンベット 入金反映時間 healthy.
The team looked for the first time at environmental-based changes to RNA molecules in bronchial epithelial cells that are critical for protection from hazardous pollutants. The finding that ラーメンベット 入金反映時間 can impact cholesterol regulation is important because disruption of that process increases risk of obesity, asthma, COPD and other adverse effects.
“Essentially, air pollution hurts cholesterol synthesis and that contributes to pulmonary diseases,” said Lydia Contreras, an associate professor in the McKetta Department of Chemical ラーメンベット 入金反映時間 who led the study.
Poor air quality expedites oxidation to RNA molecules that are key in decoding important genes for cholesterol synthesis, a process essential for maintaining the integrity of human cells. Oxidation naturally occurs as people age, but when it happens due to pollution, it leads to organs that are essentially aging faster than they otherwise would. The ラーメンベット 入金反映時間 also identifies several genetic markers that could aid in the development of diagnostics and treatments for lung-related diseases.
Contreras teamed up with chemical ラーメンベット 入金反映時間 assistant professor Lea Hildebrandt Ruiz’s lab to utilize a state-of-the-art facility, where they exposed cells to two different mixtures of airborne pollutants for approximately 90 minutes, using an "air-liquid interface system” designed to mimic the respiratory tract. Most environmental studies focus on just single chemicals, but the team decided to use a mixture because it is more realistic of what people are exposed to in day-to-day life.
Contreras is part of a growing community of researchers that combine expertise in human health, down to the molecular and cellular level, with a focus on the impact of the surrounding environment. Contreras and her team of researchers have worked with Hildebrandt Ruiz and Elizabeth Matsui, director of clinical and translational ラーメンベット 入金反映時間 at UT’s Dell Medical School to further understand air pollution disparities in Texas and the impact on cellular mechanisms that affect health.
This ラーメンベット 入金反映時間 comes as the novel coronavirus continues to ravage the U.S. and takes a particularly strong toll on people with existing respiratory issues. A recent analysis found a link between areas of high ラーメンベット 入金反映時間 and increased COVID-19 cases, hospitalizations and deaths.
“This finding is especially relevant for minority communities that face pollution disparities due to historic redlining,” Contreras said.
A recent study that included researchers from the ラーメンベット 禁止ゲーム found that minority communities bear disproportionate impacts of ラーメンベット 入金反映時間. Contreras notes that those communities tend to live closer to sources of pollution such as highways and waste facilities.
"Many people already have hidden conditions, and then you add environmental risk factors that also contribute to health," Contreras said. “Those underlying issues make you less successful in fighting off any respiratory disease."
For more updates on this ongoing ラーメンベット 入金反映時間, follow the Contreras ラーメンベット 入金反映時間 group on Twitter at @Contreras_Lab.
