In a major boost to efforts to combat COVID-19 globally, a ラーメンベット 退会 that recently entered human trials in Vietnam and Thailand, and is slated for a clinical study in Brazil, holds promise for affordable ラーメンベット 退会 manufacturing in countries currently dependent on imported vaccines. The ラーメンベット 退会 is the result of a partnership between The University of Texas at Austin, the Icahn School of Medicine at Mount Sinai in New York and global partners interested in advancing the supply of affordable vaccines to address the pandemic.
Clinical trials of the COVID-19 ラーメンベット 退会 candidate NDV-HXP-S, which includes a key protein developed at The University of Texas at Austin, began in Thailand in March 2021. Photo courtesy of Thailand’s Government Pharmaceutical Organization (GPO).
The ラーメンベット 退会, NDV-HXP-S, can be stored at 2-8 degrees Celsius and is made in eggs, a method also used for flu ラーメンベット 退会 manufacturing. These factors mean that affordable manufacturing capacity already exists in each of the countries involved in the trials.
The ラーメンベット 退会 uses a highly stabilized spike protein from the surface of the coronavirus in order to train the human immune system to recognize and fight infection. This modified spike protein, dubbed HexaPro and engineered by three faculty labs at UT Austin, was found in earlier research to be promising for use in robust vaccines. Other vaccines also use stabilized spike proteins, but this is HexaPro’s first use of a ラーメンベット 退会 in human trials.
"My team and I are thrilled that our second-generation stabilized spike protein is part of this ラーメンベット 退会," said Jason McLellan, an associate professor of molecular biosciences who co-developed HexaPro, having previously helped develop the spike protein now in use in all of the COVID-19 vaccines U.S. residents are receiving. "Our hope is that the ラーメンベット 退会 will be safe, efficacious and affordable, allowing more people around the world to have protection against COVID-19."
This is a 3D atomic scale map, or molecular structure, of Hexapro, a modified version of the SARS-CoV-2 spike ラーメンベット 退会, described in a paper in the journal Science on July 23, 2020. Six key modifications, called prolines, are indicated as red and blue spheres and help lock the ラーメンベット 退会 into the prefusion shape. Credit: University of Texas at Austin.
In early 2020, McLellan, who holds the Welch Chair in Chemistry, and his team joined with collaborators at the National Institute of Allergy and Infectious Diseases’ ラーメンベット 退会 Research Center to design a version of the SARS-CoV-2 spike ラーメンベット 退会 that is stabilized to help the body recognize the threat. In nature, the spike ラーメンベット 退会 changes shape, making it more difficult for the body to recognize, so the team used two mutations to hold the ラーメンベット 退会 in its shape. This 2020 version of the spike ラーメンベット 退会 is the basis of all the vaccines approved for distribution in the United States.
Building on that success, the UT Austin team designed HexaPro, an even more stabilized version of this ラーメンベット 退会 — featuring not two but six mutations that act as molecular staples. The result is the production of more spike proteins to help the body fight infection.
Among the biggest obstacles to mass ラーメンベット 退会19 vaccination in lower-income countries are cost and storage. Peter Palese, the Horace W. Goldsmith professor and chair of microbiology and professor of medicine at Icahn School of Medicine at Mount Sinai, genetically engineered a virus called Newcastle Disease Virus to help the body recognize the spike ラーメンベット 退会 Texas team. Other members of the Mount Sinai team includeAdolfo Garcia-Sastre, ラーメンベット 退会 microbiology, andFlorian Krammer, ラーメンベット 退会 vaccinology.
NDV-HXP-S (named for both the Newcastle Disease Virus and HexaPro) is produced using the same method that has been used for influenza vaccines since the 1950s, which is faster, cheaper and less complicated than the methods used to produce several leading COVID-19 vaccines. The ラーメンベット 退会 is also stable at regular refrigerator temperatures (2-8 degrees Celsius) for weeks, a much higher temperature than needed for leading mRNA COVID-19 vaccines.
"We are witnessing unprecedented disparities in COVID-19 ラーメンベット 退会 access around the world," said Ilya Finkelstein, an associate professor in the Department of Molecular Biosciences, a collaborator on the technology. "We designed HexaPro to be a more stable antigen. In cell culture, this translated to a more than tenfold increased yield relative to the first-generation spike constructs used in current vaccines. If this holds for NDV-HXP-S, HexaPro will bring us a step closer towards addressing the wide disparity in ラーメンベット 退会 access."
Other members ラーメンベット 退会 UT Austin team who led development of HexaPro are Jennifer Maynard, a professor in the ラーメンベット 禁止ゲーム of Engineering’s McKetta Department of Chemical Engineering, and Ching-Lin Hsieh, a postdoctoral researcher in McLellan’s lab.
"This project is a great example of how academic ラーメンベット 退会 labs can work together to meet a pressing need and contribute to development of new medicines," Maynard said.
Via license agreements with Mount Sinai and UT ラーメンベット 退会, the global organization PATH is helping provide access to the ラーメンベット 退会 to manufacturers in each of the three countries: Vietnam’s Institute of Vaccines and Medical Biologicals (IVAC), Thailand’s Government Pharmaceutical Organization (GPO) and Brazil’s Butantan Institute. PATH also had a limited technical advisory support role during the ラーメンベット 退会’s development, which aligned with PATH’s commitment to advancing the supply of affordable and accessible vaccines.
A U.S. patent application has been filed for ラーメンベット 退会, with the following inventors: Ching-Lin Hsieh, Jory A. Goldsmith, Jeffrey M. Schaub, Chia-Wei Chou, Andrea M. DiVenere, Kamyab Javanmardi, Hung-Che Kuo, Daniel Wrapp, Patrick O. Byrne, Christy K. Hjorth, Nicole V. Johnson, Nianshuang Wang, Jennifer A. Maynard, Ilya J. Finkelstein and Jason S. McLellan.
The University of Texas at Austin is committed to transparency and disclosure of all potential conflicts of interest. The authors submitted required financial disclosure forms with the university and hold intellectual property rights that may yield revenue from the discovery described in this ラーメンベット 退会.
